Reaction of Local Anesthetics with Phospholipids
نویسندگان
چکیده
منابع مشابه
Reaction of Local Anesthetics with Phospholipids
Local anesthetics (LA) have been found to interact with phospholipids and lipids extracted from nerve and muscle. This reaction is demonstrated by: (a) Inhibition by LA of phospholipid (and tissue lipid) facilitated transport of calcium from a methanol: water phase into chloroform. This action is dependent upon the cationic form of the LA. (b) LA increase the electrical resistance of "membranes...
متن کاملLocal Anesthetics Properties of Local Anesthetics
The first clinical uses of a local anesthetic agent occurred in 1884, when cocaine was employed as a topical agent for eye surgery and to produce a nerve block. These events inaugurated a new era, that of regional anesthesia. New applications were developed, including spinal, epidural, and caudal anesthesia. The search for a better local anesthetic led to chemical synthesis of a number of other...
متن کاملToxicity of local anesthetics
Systemic neurotoxicity due to excessive cerebral local anesthetic blood levels is one of the most severe and most frequent adverse outcome of local anesthetic use. Toxic levels are most often produced by unintentional intravenous or intraarterial injection(1,2). Toxicity can also result from the rapid absorption of drug following perineural injection. Peak blood levels are usually obtained acco...
متن کاملMechanisM of LocaL anesthetics
Local anesthetic systemic toxicity (LAST) is a rare yet devastating complication from the administration of local anesthesia. The ability to recognize and treat LAST is critical for clinicians who administer these drugs. The authors reviewed the literature on the mechanism, treatment, and prevention of LAST, with the goal of proposing a practical method for its management.
متن کاملInteraction of Local Anesthetics with Biomembranes Consisting of Phospholipids and Cholesterol: Mechanistic and Clinical Implications for Anesthetic and Cardiotoxic Effects
Despite a long history in medical and dental application, the molecular mechanism and precise site of action are still arguable for local anesthetics. Their effects are considered to be induced by acting on functional proteins, on membrane lipids, or on both. Local anesthetics primarily interact with sodium channels embedded in cell membranes to reduce the excitability of nerve cells and cardio...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of General Physiology
سال: 1964
ISSN: 1540-7748,0022-1295
DOI: 10.1085/jgp.48.2.357